Pyoderma gangrenosum is a rare but serious ulcerating skin disease causing painful ulcers on the legs and other parts of the body. Diagnosis of the condition is difficult due to a lack of biomarkers or other distinguishing features, and treatment can also be challenging. No single specific therapy for pyoderma gangrenosum is available and few clinical trials have been performed into the condition.

Pyoderma gangrenosum is generally managed through a stepwise approach using a…

Pyoderma gangrenosum is a rare but serious ulcerating skin disease causing painful ulcers on the legs and other parts of the body. Although pyoderma gangrenosum can affect individuals of any age, it is most common in people in their 40s and 50s. It tends to be associated with inflammatory conditions, including ulcerative colitis, Crohn's disease, rheumatoid arthritis, and hepatitis.

Diagnosis of pyoderma gangrenosum can be problematic as no specific diagnostic features can be…

What is lymphedema?

Lymphedema describes an abnormal accumulation of lymphatic fluid in the interstitium causing swelling and a feeling of heaviness or weakness in the affected area. Lymphedema most commonly affects the arms and legs, but can sometimes also occur in other parts of the body.1…

Ultrasound was used successfully for years as a non-invasive diagnostic tool before its potential benefits in wound healing were first investigated.1 Ultrasound waves, formed when electrical energy is converted to sound waves at frequencies above the range of human hearing, are now used routinely in wound management and can be transferred to tissue though a treatment applicator. The depth of penetration is dependent on the frequency, with higher frequencies resulting in lower tissue…